OXIDIZED REGENERATED CELLULOSE HAEMOSTAT

Oxidized regenerated cellulose is used during surgical operations to allow the surgeon to control hemostasis in a balanced manner and stop bleeding. Oxidized regenreated cellulose is one of the absorbable hemostatic agents. When hemostatic agents are used, the risk of surgical intervention due to haemostasis decreases. However, the use of oxidized regenerated cellulose based absorbable hemostats has become widespread.

Cellulose is a raw material for haemostat with oxidized regenerated cellulose structure. At the same time, it is a carbohydrate obtained by continuously repeating anhydrous-glucose units that have a hydroxyl group to form a chain molecule. Also, it is insoluble in organic solvents such as water and benzene, alcohol acetone, chloroform. Cellulose, which is of plant origin, is abundant in nature as biomass. Scientists have carried out various studies for many years in order to bring functionality to cellulose. In this way, cellulose has become available for various bio-applications over the years.

Oxidized regenerated cellulose was made in the late 1930s. In addition, it is formed by the partial oxidation of primary hydroxyl groups in anhydroglucose rings of monocarboxyl cellulose.

Oxidized regenerated cellulose provides biocompatibility, biosecurity and bioabsorption due to the presence of 16-24% carboxylic acid. It also plays a big role in stopping bleeding.

Intercalarily, considering the use of an absorbable haemostat with an oxidized regenerated cellulose structure, it does not induce immune response during surgical operations with the good haemostasis it provides in a short time. Additionaly, oxidized regenrated cellulose forms a black gelatinous mass when in contact with blood. This mass acts as a physical structure to which blood platelets can adhere by creating a clot. Thus, with the formation of the flake-fibrin plaque, the blood flakes accumulate and the bleeding is stopped.

Consequently, absorbable haemostats with oxidized regenerated cellulose structure are absorbable medical devices used in related operations such as digestive system surgery, orthopedics, aesthetic surgery, traumatology, gynecology, dental practices, general surgery and endoscopic operations.